![]() ![]() Sleep disorders are seen in a large percentage of patients with PD and other synucleinopathies, with one of the most common disorders being insomnia. Parkinson’s Disease and Other Synucleinopathies For example, there is growing evidence that poor sleep can accelerate progression of neurodegenerative disorders, such as AD, and may play a role in pathogenesis of the disease. Sleep may also play a key role in the onset and progression of neurodegeneration. It is important for clinicians to recognize and properly manage sleep disorders because treatment may improve neurodegenerative disease symptoms and quality of life for both the patient and their caregivers. Despite a growing appreciation of the significance of sleep in this population, sleep disorders frequently remain undiagnosed and untreated. For example, rapid eye movement (REM) sleep behavior disorder can present years or decades before any other neurologic symptoms or signs are present, and may serve as an early biomarker for neurodegenerative conditions such as PD or other synucleinopathies. The higher prevalence of sleep disorders in this population is not only secondary to the underlying neurologic symptoms, but also a consequence of damage to sleep-controlling regions of the brain, often affected in neurodegenerative disorders. In addition to progressively worsening neurologic symptoms such as gait abnormalities, tremor, spasticity, and memory deficits, many people with neurodegenerative disease also suffer from sleep complaints such as insomnia, excessive daytime sleepiness, or abnormal motor activity during sleep. Cerebral neurodegenerative disorders such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are increasing in prevalence as our population ages. ![]()
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